Synthesis and characterization of nanoparticles of calcium pyrophosphate. This fact has attracted increasing interest in other calcium phosphate based materials 4 4 Vasant SR, Joshi MJ. Journal of Biomedical Materials Research. The effects of calcium phosphate particles on the growth of osteoblasts. In fact, Hap particles have an inhibitory effect on the growth of osteoblast cell cultures 5 5 Sun JS, Tsuang YH, Liao CJ, Liu HC, Hang YS, Lin FH. The CPP proved to be more biocompatible to bone tissue than to Hap 4 4 Vasant SR, Joshi MJ. The CPP presents a biological response similar to that of the hydroxyapatite (Hap) for the formation of a new bone. One of the forms of calcium phosphate that has a high potential to be used as bone replacement material or bone graft is calcium pyrophosphate (CPP, Ca 2P 2O 7). Materials Science and Engineering: R: Reports. Fabrication, biological effects, and medical applications of calcium phosphate nanoceramics. Due to the structural and chemical similarities with bone, calcium phosphate-based biomaterials have good biocompatibility, bioactivity and osteoconductivity with implanted tissue 3 3 Hong Y, Fan H, Li B, Guo B, Liu M, Zhang X. It is well known that the biomaterials most commonly used for bone substitution are those based on calcium phosphate (Ca-P), such as hydroxyapatite, tricalcium phosphates, amorphous phosphate, dicalcium phosphate, among others. These materials were then called biomaterials or bone substitutes. Innovative methodology for developing a bone grafting composite biomaterial starting from the seashell of Rapana thomasiana. About thirty years ago, the field of materials engineering developed bone tissue engineering to induce bone regeneration, also called bone grafts, which have been shown to have excellent osteogenic capacity, osteoinduction, and osseointegration 2 2 Tihan GT, Sereanu V, Meghea A, Voicu G, Albu MG, Mitran V, Cimpean A, Zgârian RG. Bone substitutes in orthopedic surgery: from basic Science to clinical practice.

This biphasic calcium phosphate bioceramic synthesized using fish bone waste presented nanostructured nature with an average crystallite size of 69.58 nm, which is very promising for biomedical applications.Ĭalcium phosphate biphasic bioceramic fish bone waste nanocrystallitesĪround the world, bone defects are caused by trauma, excision, mutilation, extraction, or some abnormal developed tissue, resulting in a major global health problem around two millions bone repair procedures performed annually 1 1 Campana V, Milano G, Pagano E, Barba M, Cicione C, Sallona G, Lattanzi W, Logroscino G. The results indicated the formation of a biphasic calcium phosphate bioceramic comprising 67.6 % of β-calcium pyrophosphate (β-CPP) and 32.1 % of β-tricalcium phosphate (β-TCP). The synthesized bioceramic was characterized in terms of X-ray diffraction (XRD), scanning electron microscopy (SEM/EDS), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTRI), average crystallite size and refinement by the Rietveld method for the quantification of crystalline phases. The calcium phosphate bioceramic was prepared by a wet precipitation method with acid and base reactions. Fish bone is rich in calcium carbonate, which makes it an alternative source of low cost calcium carbonate for the synthesis of calcium phosphate bioceramic for use in bone regeneration.

Fish bones